Fluoxetine (Prozac) and sertraline (Zoloft), both SSRI's, didn't agree with me at all. I experienced heightened anxiety, a distorted sense of speed/motion, paranoia and homicidal ideation, which got worse the longer I stayed on them, and which cleared up fairly quickly after discontinuing them.
Venlafaxine (Effexor), an SRNI, had a considerably different effect; it was very sedating, and I slept for 12+ hours a day and felt completely shit and exhausted the whole time I was taking it.
Lofepramine, a tricyclic anti-depressant, was similar to venlafaxine, but I think it was even more sedating and shitty.
I've also taken mirtazapine (Remeron), a tetracyclic noradrenergic and specific serotonergic antidepressant, and it took the edge off of some anxiety I was having at the time, but it also dried up my mucus membranes and gave me mild constipation, and I decided it wasn't worth the bother, especially since it could screw with cholesterol levels.
Atomoxetine (Strattera), a norepinephrine reuptake inhibitor, combined a more severe form of mirtazipine's mucus-membrane-drying and constipating effects with the sedating, exhausting, feel-like-shit effects of venlafaxine and lofepramine, and also brought a generous serving of apathy to the party.
The only bad things I have to say about dexamphetamine are that it's easy to develop a resistance to it, and coming off it in order to lower my resistance is pretty horrible; I get muscular pains and tingles, particularly in my legs, and I feel tired and shitty. When I'm taking it and it's working, the benefits are impressive and the side-effects are barely noticeable.
