Yeah clonidine I reccomend too my dear. I take it daily. And it isn't an antipsychotic/neuroleptic which really aren't nice generally. And can produce profound and indeed sometimes permanent side effects of a truly terrible nature. ANY of the APs however, are superior to haloperidol, and perhaps the other butyrophenone antipsychotics, of which haldol is one, I have not calculated the potential for each to dock with monoamine oxidases and be metabolized intracellularly into a charged, lethally cytotoxic metabolite like HPP/HPP+ (it enters the cell uncharged as HPP, the haldol metabolite, which IS formed, this as known a fact and indisputable as is the fact that morphia comes from the opium poppy and that strychnine is a convulsant poison in excess dose. Simple, researched, known, scientific fact. It DOES produce this neurotoxin, and the damage is chronic and cumulative, this stuff causes brain damage and whilst tranquilizing a raging out of control frank psychotic during a schizophrenic violent episode is one thing, dosing anybody daily with this AP cannot be justified. It LITERALLY shrinks brain matter, erodes it, and specifically targets the nigrostriatal tract, a part of the brain composed of the striatum, involved in pleasure, reward, incentive salience and task-orientation, goal seeking capacity. And the substantia nigra, which, like the striatum is a part of the brain LOADED with DAT (dopamine transporter) with which the cells can take up the uncharged HPP and MAO-b the neurological isoform of monoamine oxidase (primarily selective for dopamine, as opposed to monoamine oxidase-a which is primarily selective for noradrenaline/adrenaline and for serotonin, the MAOIs used as antidepressants, with the exception primarily of selegiline are MAO-A inhibitors (the PNS isoform), moclobemide being a reversible (I.e competitive) MAO inhibitor, at least I think its competitive, It may work via an allosteric site, can't remember but if you wish me to find out just say so and it will take me but moments to determine its binding profile with monoamine oxidase type A. Selegiline is a MAO-b inhibitor save for at high doses when it produces a crossover into being a dual inhibitor of MAO-b and MAO-a and is the main common MAO-b inhibitor. Clinical MAOIs are almost all of the MAO-a inhibitor type though)
And ANY alternative to haloperidol is a good and truly advisable thing, this stuff is a NEUROTOXIN of a nasty ass nature. The uncharged form is uptaken via dopamine transporters (DAT) into the cytoplasm, metabolised to quaternary cationionic form, HPP+, which carries an electrical charge, this renders it trapped within the cell where it then goes on to produce reactive oxidant species which destroy the cells, particularly those of the substantia nigra. This is the region of the brain containing that population of dopaminergic neurons which controls voluntary movement, and with its destructive effects makes those taking it longterm more susceptible to a kind of chemically induced parkison's disease (permanent in nature rather than transient and can be severe), a modality of toxicity first observed in a particularly nasty incident, the 'case of the frozen addicts'
In this, some clandestine chemists took to producing a reverse ester derivative of one of the prodine family opioids (related to pethidine, aka meperidine, as well as things like ketobemidone and the other bemidones), only they during a run, tried to shortcut an acylation step, needing to dose their opioid, a bf and gf, and this involved increasing the temperature by removing cooling at the critical acylation step resulting in a loss of a molecule of propionic anhydride by dehydration-elimination producing a methylphenyltetrahydropyridine, or MPTP for short. This is metabolised to the corresponding methylphenyltetrahydropyridinium cation once uptaken by DAT and acted upon intracellularly by MAO-b producing the pyridinium cation, and locking it in cells for oxidant species to be generated, killing the cell. This produced a rapid and incredibly severe parkinsonian toxicity which left the two effectively locked into their own bodies, crippled for life, after the standard L-DOPA/carbidopa (or other DOPA decarboxylase peripheral inhibitor (without one of the latter, L-DOPA gets metabolized to dopamine before it crosses the blood-brain barrier and so just gets chewed up and shat out by monoamine oxidases quick as you can say 'the renster gives me the warm fuzzlies' so cannot do its job.
It left them locked in, with massively severe, advanced parkinson's disease. They were (dubiously) lucky to be discovered and not to have stayed there, locked in, until they starved to death.
Haldols metabolite HPP is obviously introduced to the body in smaller quantities since it as a metabolite is dose-dependent in the quantity produced in-vivo, more cannot be produced than what exists to produce it FROM, of course. But damage is done, slowly over time and haloperidol, IMO should long, long have been tossed onto the vast scrapheap of failed and recalled medicines for this reason. You take this stuff into your old age and it'll fuck you in the ass via your eyesockets with a bifurcated dog knob on a red hot stick. It eats brains. And yours is a lovely, tasty brain that should be kept in one piece.
For an activating AP (via different reasons than most), have you tried amisulpiride or sulpiride? it has weak effects on the GHB receptor, producing at low doses, activating effects separate from its antidopaminergic D2 type antagonism (common to all APs). I think it may well help with depression too. These effects are unique to amisulpiride and sulpiride, other APs do not possess this GHBr affinity.
But any of them are less noxious than haloperidol. This stuff ain't a medicine, its a poison. A cumulative, nasty ass kind of poison too. Its an archaic, NOTORIOUSLY side-effect-laden, even amongst its class, member of the APs that never should have remained on the market, stocks should have been shipped to the third world medical systems until they disappeared, or else forced down the throat of politiciansf;sf,am pcj j .
All the APs can have foul side effects but the rest at least do not have this chronic, cumulative specific mode of cytotoxicity, makes haldol one nasty, posonous, outmoded,noxious heap of shite.
Miss K my dear one, you have pain meds now? did you get my PM? tell me you got something proper, not ome worthless fob-off dungheap paracetamol or worse. My offer is still open if you need it and have no legit pain meds.
