Not half bad. Bought a small amount of a new derivative of 5-APB 5-(2-aminopropyl)benzofuran, a desoxy derivative of MDA. The compound I have, namely 5-IT, 5-(2-aminopropyl)indole, a positional isomer of AMT, is seemingly closer in pharmacology to 5-APB than to AMT.
Although I can't say for sure. Dose so far, I've taken it up to 60mg nasally, as 2x30mg 2 hours apart, I haven't taken 5-APB so I can't give a qualitative comparison. I got sent some as a free sample by a research chemical supply company I have done some business with, although the pigs seized it, along with most of a gram each of alpha-methyltryptamine, and 5-methoxy-n,n-diallyltryptamine. Tried charging me, forced to drop it as they have no grounds either for a legal search, and seized nothing illegal.
So they will have to return everything, including the 5-(2-aminopropyl)-benzofuran, I just have to call the bacon on monday to arrange that. And I intend to sue the cunts for this. When I get it back, when I get round to it, I will give the 5-APB a bioassay. As a rule I don't like entactogens. I am not built to be social, I'm just not wired up right for them, in terms of biochemistry. But thus far, the 5-IT seems ok.
I HATE MDMA, and its beta-keto analog methylone. The empathogenic effect seems forced and fake to me, I find its just not my ally and I can't accomplish much positive with it, so I don't bother taking MDMA or bk-MDMA. I do enjoy AMT though, which is a true 5HT2a agonist psychedelic in addition to its entactogenic effects, AMT has helped me get to a state where I can work through the issues that are responsible for causing my PTSD.
Summary of the 5-IT experience:
Body weight-around 10 stone
Gender-male
Age-25, nearly 26
Dosage-30mg 5-IT freebase, intranasally, followed by a further 30mg intranasally at T:2 hours.
Also on a little short of 1g of oxycodone HCl, intravenously along with a dose of a non-sedating antihistamine, and a load of antiinflammatories (traxam gel, and indomethacin capsules)
Effects:
Moderate stimulation, some elevation of heart rate, nothing alarming. The cardiovascular push at this dosage level is not threatening. I did however find it a little irritating, so took 8mg of tizanidine (an alpha2 adrenoreceptor agonist) to lessen it. Some increase of the muscle twitching I've been having a problem with. Took 10mg nitrazepam at T:+4 1/2 hours
Anorexia-Ate beforehand knowing this was a likely property of 5-IT, it is with most drugs of a stimulant nature. And as expected, it is indeed the case. I am not hungry at all, although thirst is normal, making sure to drink and stay hydrated.
Mindset: quite comfortable just sitting at my computer, talking to people on MSN, listening to music, And FINALLY managing to kill the fucking rootkit that has been plaguing my computer.
Some jaw grinding. I think in a bit I will go to the lab and find some magnesium sulfate, as Mg helps with stimulant-induced jaw tension and bruxism.
Overall, quite contented just sitting here, talking on MSN, listening to music, and checking updates on various forums. Some elevation of body temperature, as with MDMA, methylone, and other CNS stimulants, largely counteracted by the dose of paracetamol I took to help lessen the pain in my leg. Christ....I hope they bloody fix it soon. I have had enough of this shit. I shouldn't have to rely on a cane to walk at 25yo.
I think in a bit though I shall have to get off my arse and to the lab, I have a project I'm working on, the synthesis of a novel AMPAkine type nootropic, 1-benzoyl-4-propionylpiperazine, aka sunifiram. This one is of extreme potency by weight, and the journal references on it make it look pretty promising. Active at 0.1mg/kg (oral, rat) to 0.001mg/kg (IV, rat)
http://en.wikipedia.org/wiki/SunifiramNo human bioassays out there that I can find, not so sure as its ever been tried in man. If it has, then nobody has reported about it online that I can find. My source of piperazine is impure though, I have it as an OTC de-worming medicine, which is mostly piperazine phosphate, but has a pinkish dye in it. Going to try purification via sublimation of the freebase, followed by formation of mono-hydrochloride salt, which should act as a protecting group, allowing selective mono-acylation with first benzoyl chloride, then removal of the HCl protecting group with base, allowing reaction with propionyl chloride to give sunifiram.
If however the intended reaction protocol proves a pain in the arse, I shall buy some n-BOC piperazine come monday when I get paid, or better still, some 1-benzoylpiperazine, if I can find it.
I think I might redose a little more 5-IT in a little while, and see where it takes me. No more re-doses after that though. Going to dose another 40mg of oxy, as my leg is still absofuckinglutely killing me. I can't wait until my appointment with the specialist pain clinic, my regular doctors are at a loss as to how to handle it now, my hip and knee have got so bad. Just took 20mg baclofen (a muscle relaxant) to help lessen the muscle tension in my leg, and am about to slam 40mg of oxycodone.
*mmm...that hit the spot
* Thats better. I can stand up now, and stretch my legs some.
