A skeleton walks into a bar. He goes up to the bartender and says, “I’d like a beer and a mop.”
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Quote from: Lestat on September 27, 2012, 04:09:34 AMThere are quite a few cognitive enhancers (known as nootropics) on the market now.Very few are used in western countries in general medical practice, most are bought online.The 'racetams are the classic example, piracetam was the first IIRC, although one of the weakest, its also one of the cheapest. The mechanism of action is poorly understood, some are known to be positive allosteric modulators of the AMPA type ionotropic glutamate receptor, enhancing longterm potentiation and improving memory formation/consolidation, attention focus and inducing release of acetylcholine.They all show an excellent level of safety, being pretty much completely nontoxic, even in large overdoses, with the sole exception of nefiracetam, which has been shown to cause testicular atrophy in dogs, which IIRC can be permanent. IMO pramiracetam is the best of the 'racetam family, although also the most expensive, phenylpiracetam sounds like another real gem, but I haven't tried it for myself, its hard to find.Another option might be cholinesterase inhibitors, such as tacrine, rivastigmine, huperzine-A, and galantamine (galantamine also acts as an alpha7 type neuronal nicotinic acetylcholine receptor agonist, which gives it a second way of increasing memory formation, very pricy, but galantamine was very effective for me, but I can't afford it:( )These can have side effects, as they are basically pharmaceutical nerve agents, nasties like the novichok agents, VX, sarin, tabun, soman and the like are also cholinesterase inhibitors, although these fluorophosphate type nerve agents bind irreversibly (irreversible under normal physiological conditions that is, although with the exception of the novichok type agents it is possible to reactivate the poisoned acetylcholinesterase enzyme with chemical antidotes) whereas the pharmaceuticals are reversible in their binding to cholinesterase)With the racetams, one should take a choline supplement with them, as they enhance uptake of choline and thus synthesis of the neurotransmitter acetylcholine, meaning that they deplete choline faster than normal, which can lead to headaches for many people.'Racetams compliment very well with anticholinesterases too IMO.The AMPAkines are the most promising sounding development on the nootropic front as of yet. Not tried any of them yet, but I will be trying DM-235 as soon as I complete the synthesis. Can't wait.My daily bitch:I'm having problems injecting. For some reason, the needles seem to be jamming part way through my oxy shots, making it impossible to push the plunger down without drawing it back first, emptying the rig out, then forcing several loads of water through it before loading the partly-done shot back in and starting again. Sometimes I have had to do this several times in a row.Weird thing is, the same rig that just jammed up works fine as soon as its pulled out of my vein and squirting water through it to clean it, but then jams again the moment I poke myself. Its really annoying; I HATE needles and it means repeatedly taking it out, cleaning and then shooting up again, I don't want to have to do it more than a couple of times (with my pills being controlled release, several aliquots of water are needed to make sure one gets everything out) But not 'stab...pull out, wash, stab...pull out, wash, lather, rinse, repeat'It's not the needle. Your veins are becoming sclerotic and filled with scar tissue from abuse.
There are quite a few cognitive enhancers (known as nootropics) on the market now.Very few are used in western countries in general medical practice, most are bought online.The 'racetams are the classic example, piracetam was the first IIRC, although one of the weakest, its also one of the cheapest. The mechanism of action is poorly understood, some are known to be positive allosteric modulators of the AMPA type ionotropic glutamate receptor, enhancing longterm potentiation and improving memory formation/consolidation, attention focus and inducing release of acetylcholine.They all show an excellent level of safety, being pretty much completely nontoxic, even in large overdoses, with the sole exception of nefiracetam, which has been shown to cause testicular atrophy in dogs, which IIRC can be permanent. IMO pramiracetam is the best of the 'racetam family, although also the most expensive, phenylpiracetam sounds like another real gem, but I haven't tried it for myself, its hard to find.Another option might be cholinesterase inhibitors, such as tacrine, rivastigmine, huperzine-A, and galantamine (galantamine also acts as an alpha7 type neuronal nicotinic acetylcholine receptor agonist, which gives it a second way of increasing memory formation, very pricy, but galantamine was very effective for me, but I can't afford it:( )These can have side effects, as they are basically pharmaceutical nerve agents, nasties like the novichok agents, VX, sarin, tabun, soman and the like are also cholinesterase inhibitors, although these fluorophosphate type nerve agents bind irreversibly (irreversible under normal physiological conditions that is, although with the exception of the novichok type agents it is possible to reactivate the poisoned acetylcholinesterase enzyme with chemical antidotes) whereas the pharmaceuticals are reversible in their binding to cholinesterase)With the racetams, one should take a choline supplement with them, as they enhance uptake of choline and thus synthesis of the neurotransmitter acetylcholine, meaning that they deplete choline faster than normal, which can lead to headaches for many people.'Racetams compliment very well with anticholinesterases too IMO.The AMPAkines are the most promising sounding development on the nootropic front as of yet. Not tried any of them yet, but I will be trying DM-235 as soon as I complete the synthesis. Can't wait.My daily bitch:I'm having problems injecting. For some reason, the needles seem to be jamming part way through my oxy shots, making it impossible to push the plunger down without drawing it back first, emptying the rig out, then forcing several loads of water through it before loading the partly-done shot back in and starting again. Sometimes I have had to do this several times in a row.Weird thing is, the same rig that just jammed up works fine as soon as its pulled out of my vein and squirting water through it to clean it, but then jams again the moment I poke myself. Its really annoying; I HATE needles and it means repeatedly taking it out, cleaning and then shooting up again, I don't want to have to do it more than a couple of times (with my pills being controlled release, several aliquots of water are needed to make sure one gets everything out) But not 'stab...pull out, wash, stab...pull out, wash, lather, rinse, repeat'
Tooth still killing me.
Quote from: odeon on September 27, 2012, 11:18:42 PMTooth still killing me. Should it still hurt this much now? Maybe you should call the dentist?
