Just one quick bitch, part two

[odeon]

Fucking 12-yo BOY! 

[Lestat]

I've always been good with scientific stuff in general ren, pharmacology, cognitive neuroscience etc.
Aside from physics. I suck at math too much, being severely dyscalculic.

But memory issues are so bad that I have to relearn things constantly, and sometimes, if I switch browser tabs, I can't remember a single word of what I just read online. And while working at an MDA synth, I KNOW the steps are 'oximation of helional using hydroxylamine, beckmann rearrangement, followed by the final step, a hoffman degredation using hypochlorite'

I have completely forgotten what the beckmann rearrangement involves, and despite learning it multiple times over, I have still not been able to form a memory of it, hell, I've even forgotten the NAME of the rxn several times.

Or things like going downstairs from my room, getting there and having no idea why I went in the first place, the other day, I made a doc appt., the receptionist told me the time of it, and then I turned around to ask the other receptionist something, and within less than a minute, I had no memory of the time I was just told.

[Parts]

Had to work in a crawl space under a house that had water in parts of it, there were even frogs living down there

[Peter]

Had to work in a crawl space under a house that had water in parts of it, there were even frogs living down there

Let me know if you find any newts or salamanders.

[renaeden]

I've always been good with scientific stuff in general ren, pharmacology, cognitive neuroscience etc.
Aside from physics. I suck at math too much, being severely dyscalculic.

But memory issues are so bad that I have to relearn things constantly, and sometimes, if I switch browser tabs, I can't remember a single word of what I just read online. And while working at an MDA synth, I KNOW the steps are 'oximation of helional using hydroxylamine, beckmann rearrangement, followed by the final step, a hoffman degredation using hypochlorite'

I have completely forgotten what the beckmann rearrangement involves, and despite learning it multiple times over, I have still not been able to form a memory of it, hell, I've even forgotten the NAME of the rxn several times.

Or things like going downstairs from my room, getting there and having no idea why I went in the first place, the other day, I made a doc appt., the receptionist told me the time of it, and then I turned around to ask the other receptionist something, and within less than a minute, I had no memory of the time I was just told.

Reminds me of me. I have forgotten all my stats work from uni already, which scares me because it is stuff I should have kept in my head. Plus other stuff that I am interested in but still forget for some reason.

And going somewhere and forgetting why you are there when you get there - yeah, I know what you mean! It is very annoying. When I go to the doctor, I sometimes write out a list of what I need so I don't forget to ask for anything.

I never knew there was meds you could take for these types of problems though. Just using visual cues, keeping a diary, writing things down, etc.

[Lestat]

There are quite a few cognitive enhancers (known as nootropics) on the market now.

Very few are used in western countries in general medical practice, most are bought online.

The 'racetams are the classic example, piracetam was the first IIRC, although one of the weakest, its also one of the cheapest. The mechanism of action is poorly understood, some are known to be positive allosteric modulators of the AMPA type ionotropic glutamate receptor, enhancing longterm potentiation and improving memory formation/consolidation, attention focus and inducing release of acetylcholine.

They all show an excellent level of safety, being pretty much completely nontoxic, even in large overdoses, with the sole exception of nefiracetam, which has been shown to cause testicular atrophy in dogs, which IIRC can be permanent.

IMO pramiracetam is the best of the 'racetam family, although also the most expensive, phenylpiracetam sounds like another real gem, but I haven't tried it for myself, its hard to find.

Another option might be cholinesterase inhibitors, such as tacrine, rivastigmine, huperzine-A, and galantamine (galantamine also acts as an alpha7 type neuronal nicotinic acetylcholine receptor agonist, which gives it a second way of increasing memory formation, very pricy, but galantamine was very effective for me, but I can't afford it:( )

These can have side effects, as they are basically pharmaceutical nerve agents, nasties like the novichok agents, VX, sarin, tabun, soman and the like are also cholinesterase inhibitors, although these fluorophosphate type nerve agents bind irreversibly (irreversible under normal physiological conditions that is, although with the exception of the novichok type agents it is possible to reactivate the poisoned acetylcholinesterase enzyme with chemical antidotes) whereas the pharmaceuticals are reversible in their binding to cholinesterase)

With the racetams, one should take a choline supplement with them, as they enhance uptake of choline and thus synthesis of the neurotransmitter acetylcholine, meaning that they deplete choline faster than normal, which can lead to headaches for many people.

'Racetams compliment very well with anticholinesterases too IMO.

The AMPAkines are the most promising sounding development on the nootropic front as of yet. Not tried any of them yet, but I will be trying DM-235 as soon as I complete the synthesis. Can't wait.

My daily bitch:

I'm having problems injecting. For some reason, the needles seem to be jamming part way through my oxy shots, making it impossible to push the plunger down without drawing it back first, emptying the rig out, then forcing several loads of water through it before loading the partly-done shot back in and starting again. Sometimes I have had to do this several times in a row.

Weird thing is, the same rig that just jammed up works fine as soon as its pulled out of my vein and squirting water through it to clean it, but then jams again the moment I poke myself. Its really annoying; I HATE needles and it means repeatedly taking it out, cleaning and then shooting up again, I don't want to have to do it more than a couple of times (with my pills being controlled release, several aliquots of water are needed to make sure one gets everything out)

But not 'stab...pull out, wash, stab...pull out, wash, lather, rinse, repeat'

[TheoK]

Fucking never-ending fucking rain-hell-shit! 

["couldbecousin"]

Fucking never-ending fucking rain-hell-shit! 

  Blowing things up in the rain is  BRAVE!   

[TheoK]

 

[odeon]

Bloody tooth.

[TheoK]

You must be  I have had two teeth with rootcanals splitting. The great irony is that if I had been born 20 years later, those teeth would never had had a filling at all and thus still be there. Fucking dentists 

[odeon]

You must be  I have had two teeth with rootcanals splitting. The great irony is that if I had been born 20 years later, those teeth would never had had a filling at all and thus still be there. Fucking dentists 

Yeah, it's annoying. The hack that did the root canal 25 years ago did a poor job, or so my dentist says.

[Peter]

There are quite a few cognitive enhancers (known as nootropics) on the market now.

Very few are used in western countries in general medical practice, most are bought online.

The 'racetams are the classic example, piracetam was the first IIRC, although one of the weakest, its also one of the cheapest. The mechanism of action is poorly understood, some are known to be positive allosteric modulators of the AMPA type ionotropic glutamate receptor, enhancing longterm potentiation and improving memory formation/consolidation, attention focus and inducing release of acetylcholine.

They all show an excellent level of safety, being pretty much completely nontoxic, even in large overdoses, with the sole exception of nefiracetam, which has been shown to cause testicular atrophy in dogs, which IIRC can be permanent.

IMO pramiracetam is the best of the 'racetam family, although also the most expensive, phenylpiracetam sounds like another real gem, but I haven't tried it for myself, its hard to find.

Another option might be cholinesterase inhibitors, such as tacrine, rivastigmine, huperzine-A, and galantamine (galantamine also acts as an alpha7 type neuronal nicotinic acetylcholine receptor agonist, which gives it a second way of increasing memory formation, very pricy, but galantamine was very effective for me, but I can't afford it:( )

These can have side effects, as they are basically pharmaceutical nerve agents, nasties like the novichok agents, VX, sarin, tabun, soman and the like are also cholinesterase inhibitors, although these fluorophosphate type nerve agents bind irreversibly (irreversible under normal physiological conditions that is, although with the exception of the novichok type agents it is possible to reactivate the poisoned acetylcholinesterase enzyme with chemical antidotes) whereas the pharmaceuticals are reversible in their binding to cholinesterase)

With the racetams, one should take a choline supplement with them, as they enhance uptake of choline and thus synthesis of the neurotransmitter acetylcholine, meaning that they deplete choline faster than normal, which can lead to headaches for many people.

'Racetams compliment very well with anticholinesterases too IMO.

The AMPAkines are the most promising sounding development on the nootropic front as of yet. Not tried any of them yet, but I will be trying DM-235 as soon as I complete the synthesis. Can't wait.

My daily bitch:

I'm having problems injecting. For some reason, the needles seem to be jamming part way through my oxy shots, making it impossible to push the plunger down without drawing it back first, emptying the rig out, then forcing several loads of water through it before loading the partly-done shot back in and starting again. Sometimes I have had to do this several times in a row.

Weird thing is, the same rig that just jammed up works fine as soon as its pulled out of my vein and squirting water through it to clean it, but then jams again the moment I poke myself. Its really annoying; I HATE needles and it means repeatedly taking it out, cleaning and then shooting up again, I don't want to have to do it more than a couple of times (with my pills being controlled release, several aliquots of water are needed to make sure one gets everything out)

But not 'stab...pull out, wash, stab...pull out, wash, lather, rinse, repeat'

All I've noticed with 'racetams is that they give me an unpleasant pressure-inside-my-head feeling.

[midlifeaspie]

There are quite a few cognitive enhancers (known as nootropics) on the market now.

Very few are used in western countries in general medical practice, most are bought online.

The 'racetams are the classic example, piracetam was the first IIRC, although one of the weakest, its also one of the cheapest. The mechanism of action is poorly understood, some are known to be positive allosteric modulators of the AMPA type ionotropic glutamate receptor, enhancing longterm potentiation and improving memory formation/consolidation, attention focus and inducing release of acetylcholine.

They all show an excellent level of safety, being pretty much completely nontoxic, even in large overdoses, with the sole exception of nefiracetam, which has been shown to cause testicular atrophy in dogs, which IIRC can be permanent.

IMO pramiracetam is the best of the 'racetam family, although also the most expensive, phenylpiracetam sounds like another real gem, but I haven't tried it for myself, its hard to find.

Another option might be cholinesterase inhibitors, such as tacrine, rivastigmine, huperzine-A, and galantamine (galantamine also acts as an alpha7 type neuronal nicotinic acetylcholine receptor agonist, which gives it a second way of increasing memory formation, very pricy, but galantamine was very effective for me, but I can't afford it:( )

These can have side effects, as they are basically pharmaceutical nerve agents, nasties like the novichok agents, VX, sarin, tabun, soman and the like are also cholinesterase inhibitors, although these fluorophosphate type nerve agents bind irreversibly (irreversible under normal physiological conditions that is, although with the exception of the novichok type agents it is possible to reactivate the poisoned acetylcholinesterase enzyme with chemical antidotes) whereas the pharmaceuticals are reversible in their binding to cholinesterase)

With the racetams, one should take a choline supplement with them, as they enhance uptake of choline and thus synthesis of the neurotransmitter acetylcholine, meaning that they deplete choline faster than normal, which can lead to headaches for many people.

'Racetams compliment very well with anticholinesterases too IMO.

The AMPAkines are the most promising sounding development on the nootropic front as of yet. Not tried any of them yet, but I will be trying DM-235 as soon as I complete the synthesis. Can't wait.

My daily bitch:

I'm having problems injecting. For some reason, the needles seem to be jamming part way through my oxy shots, making it impossible to push the plunger down without drawing it back first, emptying the rig out, then forcing several loads of water through it before loading the partly-done shot back in and starting again. Sometimes I have had to do this several times in a row.

Weird thing is, the same rig that just jammed up works fine as soon as its pulled out of my vein and squirting water through it to clean it, but then jams again the moment I poke myself. Its really annoying; I HATE needles and it means repeatedly taking it out, cleaning and then shooting up again, I don't want to have to do it more than a couple of times (with my pills being controlled release, several aliquots of water are needed to make sure one gets everything out)

But not 'stab...pull out, wash, stab...pull out, wash, lather, rinse, repeat'

It's not the needle.  Your veins are becoming sclerotic and filled with scar tissue from abuse. 

[Parts]

I am dealing with a building inspector who knows very little about what he thinks he is an expert on and I am exasperated