All the meds I know of your on Ren, are known sedatives, bar amphetamine. MAOIs can go either way, and its quite dependent upon the MAOI. Never taken an irreversible one, only a RIMA (a mixture of harmine and harmaline, from the seeds of a plant called syrian rue, Peganum harmala, used to render N,N-dimethyltryptamine [DMT] orally active, nasally etc. active as opposed to only when smoked (injection also works although I've never done so, and without a sitter to safely administer a drip, I wouldn't, because of the extreme rapid onset, a few seconds at most, may easily leave one unable to remove a needle before it'd blast the person doing it into hyperspace head-first, or at least what first might be in the context of weird as fuck non-euclidian geometrically orientated, non-minkowski-space environmental conditions:P)
But (and it can change over time) with MAOIs they can act sedatingly in some contexts. Particularly when taken for some time, since monoamine depletion can occur with noradrenaline, where its replaced in synaptic vesicles that would normally carry noradrenaline, by the less stimulatory and less susceptible (AFAIK) to metabolism via MAO-a, related neurotransmitter octopamine, in humans mainly a trace-amine-associated-receptor agonist (TAAR complex, AFAIK a TAAR1 agonist or allosteric modulator) but in arthropods, such as insects, spiders, as well as crustaceans and cephalopoda, octopamine replaces noradrenaline's functions in humans, and functions as a fight/flight response mediator amongst other things. but being less efficient as a stimulant than noradrenaline (in humans) MAO-a inhibitors can become sedating. And some have more sedating character than others. One of the irreversible MAO-a inhibitors, tranylcypromine is an amphetamine analog, with a cyclopropyl (could be cyclopropylmethyl, forget which off the top of me head) group in place of methyl at the alpha carbon of amphetamines. (cyclopropane, and groups derived from it are much more reactive than typical alkanes, and cyclopropyl groups too are more reactive than n-propyl or isopropyl because the cyclopropane/cyclopropyl group is under significant ring strain)
And it has significant stimulant effects, especially to begin with, according to my reading. Never taken it though, primarily because of the long duration of time in which very carefully, quite severe dietary restrictions must be adhered to, and potentially lethal interactions with some meds, particularly stimulants (combining irreversible MAO-a inhibitor type MAOIs is an absolute no-no NEVER mix type combination, that has some really ugly ways of killing the poor unfortunate bastard that experiences such an interaction. Slow, painful and nasty, amongst the nicer qualities in such cases.
So after synaptic vesicles are depleted of NA, and become carriers of octopamine instead, it being less strongly stimulating than noradrenaline, MAOIs can become sedating.
RIMAs are more forgiving, like the harmala alkaloids (harmine, harmaline, tetrahydroharmine etc) or the pharmaceutical commoner RIMA, moclobemide, although any of these still have to adhere to the drug interaction restrictions, particularly with serotonergic drugs, and also with stimulants, although microdosing a stimulant and moclobemide has been done its still IMO pretty dangerous, same goes for harmala alkaloids (naturally occuring RIMA type MAO(a)Is found in several plants, particularly syrian rue (Peganum harmala, not related to common rue, Ruta graveolens, which is toxic) and also, along with the harmine and harmaline found in syrian rue, tetrahydroharmine as well as the other two is found in a certain vine, known to some as the vine of souls, Banisteriopsis caapi, which is used by several native amerindian cultures in mixtures known as ayahuasca, or hoasca;
a mixture of the vine of souls, and, at bare minimum a second plant containing DMT (dimethyltryptamine) which is normally active only when smoked, or if intraduced into the body via injected routes or into the brain in animal studies (ugh) which is normally metabolized instantly before ever getting to the brain if swallowed, snorted etc. but the MAOI-bearing plant allows it to act orally, in the ayahuasca and hoasca brews (there are probably as many recipes as there are shamen, some including everything from nightshade alkaloids (Datura plants etc.), nicotine containing plants, and all manner of other local adjuvant plants, many of completely unknown or little studied natures.
Tried an hoasca type brew myself a couple of times in the past, and as a psychedelic IMO it didn't live up to expectations, smoked DMT thats been extracted from the plants, and cleaned up, recrystallized etc. I found it very similar to psilocybin mushrooms (psilocin is 4-OH-DMT which is of course, orally active) but a lot more similar to psilocin/psilocybin (the latter being the phosphate ester of psilocin) and couldn't hold a candle to smoked DMT freebase, isolated with solvent extraction and purification from Mimosa hostilis, a relative of the Acacia tree family, from the rootbark (many Acacia tree species also contain DMT, n-methyltryptamine and 5-methoxy-DMT in some cases IIRC in some species, although not Mimosa hostilis, of M.hostilis, the jurema tree.) plus syrian rue seed as the MAOI source. Jurema has the advantage especially for beginners or non-chemists who are up for some 'kitchen chemistry' in that the rootbark, unlike extracting from plants which contain their DMT in the leaves, the plants with the DMT and/or 5-MeO-DMT in either the root-bark or the tree bark in some cases (Virola species in particular, aka epena, yakee, or parika, depending on the region its used in, the indigenous names vary widely from tribe to tribe and country to country) are easier to extract and clean since they don't contain anywhere near the quantities of plant fats that the leaves do. so don't need a defatting step performed on the plant material powder after first acidifying (such as treating with chloroform or dichloromethane) to strip the plant fats out, which otherwise can result in a yellower, and far harsher to vaporize in a pipe product.
