Topped up another 60-80mg oxy, part up the nose, and some down the hatch. The former being in order to have some absorb faster and get working within minutes, plus a small additional dose of morphine. About to go take some clonidine, since I feel a hint of physical stimulation and that will make sure that it isn't the beginning of any overloading, and if its not, then no harm done. Going to take some nitrazepam as well (a benzo sedative-hypnotic) although I'm only going to take either 1/4 or 1/2 of a 5mg tablet, since I don't want it to put me to sleep, just to relax me, since I want to get back to my fallout II game. Got a gangland murder to solve.
Think I might take 1/4, let it go to work and if I don't feel too sleepy then take the rest of the half, not going to take a full one, since my antiseizure med is a strong sedative-hypnotic, although i am used to it enough not to just fall straight asleep with only it, but adding the benzo, a full pill will quite definitely make me fall asleep at my keyboard pretty quickly.
Just had 4x0.18mg pramipexole as well (a dopamine receptor agonist, mostly used for parkinsons disease, but also for restless leg syndrome. I take it for a mixture of the latter and I find it helps with general restlessness.)
Not sure whether I can get away with taking any zanaflex (tizanidine, the muscle relaxant related to clonidine that I take for the usually unceasing severe spasm in my leg) since that too is REALLY strongly sedating, or can be. Might skip the clonidine and just take that, after seeing how things go with the nitrazepam, since both tizanidine and clonidine work in very similar ways, as alpha-2 adrenergic autoreceptor agonists (an autoreceptor is one that senses levels of its target neurotransmitter and if too low, or an antagonist is taken, increases release of that neurotransmitter and if too high, it effectively acts as a sensor for excessive levels of neurotransmitter release and acts as a negative feedback mechanism, the higher the neurotramsitter levels binding the autoreceptor the less neurotransmitter gets released, so they serve as a way of keeping it from going runaway and preventing excessive transmitter release, artificial agonists of autoreceptors like clonidine, tizanidine, xylazine etc. essentially trick the body into thinking there is too much of the neurotransmitter to whichever autoreceptor type they bind and activate, without that being the case, so as to drop levels below normal. I find that clonidine and tizanidine both, as well as the expected effect of dropping blood pressure and muscle relaxation, really help deal with and often prevent overloading of the autie kind. And help me sleep, cutting out excessive physical stimulation from any unfiltered background sensory input; overloads suck ass and nobody wants one, me included, and I find both clonidine and tizanidine (the latter is much more of a strong muscle relaxer but AFAIK less effective as a hypotensive, but otherwise seems stronger on an effects basis although much less so on a per weight basis compared with clonidine, the latter being active in the 10s to hundreds of mcg range, whilst the tizanidine comes in 2 and 4mg tablets, I'm scripted the 4mg ones, 5x a day, although I vary it a little either way depending on how bad the cramping is in my messed up leg, and if I'm overloaded, will take a couple more, which often as not, helps either stop it before it properly starts, or prevent it altogether. At the very worst, it helps alleviate the intensity of it.
