I've noticed changes in myself that have occurred over the past year or so. My sense of humour isn't anywhere near as good as it used to be, and I've been missing jokes that would have been obvious to me before. I've become far less social; I used to like talking to people through IM's, but now I have very little interest in that, and little interest in people in general. My libido is so low now that I don't even think about it for days or weeks at a time. I'm calmer and more relaxed, but also more active and more apt to get on with things rather than procrastinate. I'm more energetic and can do more with less effort. My sleep pattern is stable and I no longer get excessively tired during the day. My mood has improved. I find my interests and pursuits to be more satisfying now. Most of all, feeling like shit is no longer the normal state of affairs for me.
I credit/blame my current meds; the changes began when I started on these meds and have become more pronounced as the dose has increased. Also, problems that have diminished or been resolved since starting on the meds come back with a vengeance when I take a break from the meds. The rebound effect started off fairly mild, but it's been getting worse and currently hits with all the subtlety of a dump truck on the second day of a medication break.
