Most meds I've taken have made me very tired. Fluoxetine, paroxetine, sertraline, venlafaxine, lofepramine, mirtazapine, cetirizine and atomoxetine have all made me feel tired. Mirtazapine's ok though, since it's a more pleasant, stoned sort of tired, and is quite mild now that I'm used to it, whereas the other ones all gave me horrible urgh kinds of tiredness.