Yeah, putting someone who is depressed on antipsychotics is a fucking cop-out big time, with perhaps one or two exceptions, with specific drugs used in very specific ways (such as low-dose amisulpiride, for its activating effects at tiny doses, preferentially blocking D2Sh isoform of the D2 receptor, D2Sh, the short isoform being the autoreceptor for dopamine., as well as its acting as a GHB receptor agonist and causing some degree of glutamate release)
But generally, its turning people who are depressed into zombies who are two mentally stulted to act it, or voice the fact they are depressed, and using drugs that have a ton of noxious side-effects, some of them potentially lifelong, and a few even potentially lethal.
It does seem like there is promise for both some relatively new established practices, such as supervised intermittent ketamine infusions, every so often that seems to often be really, really effective in very treatment resistant patients who have tried EVERYTHING, they go in once in a while, every once in several weeks to a couple of months for a one-shot treatment, and then function really well for a long time afterwards, with profound antidepressant effects.
And there are a few investigational new antidepressants either being fast tracked, some having being given approval and several others in the pipeline. IMO there needs to be more done than just handing out SSRIs, SNRIs, NRIs. At least something like a triple reuptake inhibitor might be a good idea to trial. AMPAkines perhaps as well, but unfortunately it appears like big pharma want nothing to do with prodopaminergic agents. Due to them potentially causing euphoria etc.
Which to me, strikes me as positively counterproductive in depression.
