She is a fake, a liar, a spineless crook and a dried up, leprous old crackwhore's cut-out vulva, dried up and stored in a shitbox full of maggots, piss and little baby rattlesnakes.
And responsible for the disgusting and ridiculous psychoactive substances bill. This basically bans outright, pre-natally, EVERY single possible psychoactive substance. This specifically excludes those they already make money on, alcohol and tobacco, two substances singularly responsible for MASSIVE societal and personal harm as well as harm to the NHS.
Yet bans, say, exotic indigenous psychoactive herbs that at most in the UK have a mere handful of people who have ever tasted the like. Like, say, Iporuru is now a banned substance with a penalty attached to possession. How many people here, save for myself of course, have ever taken into their body, the plant Alchornea floribunda, the dried rootbark thereof? this is Iporuru, I've had it, and frankly don't reccomend it either. But there is ZERO danger of this african plant (zaire, cameroon I THINK is the origin)
I didn't expect anyone here has taken the likes of Iporuru, its little known of even in online drug communities. But technically, even valerian from health food stores and Boots is now actually, strictly speaking, illegal, for its psychoactive, its a sedative and oneirogen. But do you see street dealers lining up to sell highly exotics?
NO, and it drives the trade in so called 'RCs (research chemicals, in the slang parlance, repeated analogues made to tweak the structure of illegal drugs and thus provide people with legal ones. This scene originally started out with people choosing fairly benign compounds to sell. With repetitive legislative crackdowns I watched this play out, and yes, I used many many many of the compounds, such as methoxetamine, a hybrid arylcyclohexylamine between the ketamine-like and PCP-type subfamilies within the group, this scene eventually degenerated to the point where for synthetic cannabinoids, which originally were fairly benign analogs being sold, like CP-55,940 and CP-55,940-dimethyloctyl homolog, and for an uberpotent option, the ultralong lasting THC modification, HU-210, on which, on carefully spiked inert plant base which which to smoke it as one would smoke standard cannabis sativa/indica, as its active in the +50-100microgram range, I have had the rare pleasure of an incredibly beautiful psychedelic experience, not just stoned, very stoned yes, but walking home on a frosty night, blazed out of my noggin on HU-210/CP-55,940-dimethyloctyl, and everything, every single last tiny grain of ice and frost was shining and twinkling brightly, even the darkness of the winters night was lit up like a christmas tree, with every tiny detail magnified, massive degree of macropsia, some dissociation. I still remember that night, as it was SO fucking beautiful. And when I got home, I tripped for ages, hours and hours until the HU-210 began to lessen in intensity a little before eating a hearty meal and having a restful night's sleep. Eventually after the likes of JWH-210 type indolic cannabinoids got banned, then they brought out the indAZole versions which progressively got banned. Now in this family there is significant benefit gotten from adding a terminal fluoroalkane chain to the 1-position indole or indazole nitrogen, and whilst odd-numbered carbon chains with the terminal fluoride are acceptable pharmacologically, to use an even numbered terminal fluoroalkane, such as say, 5-fluoropentyl, the traditional one is quite fine, but 4-fluorobutyl is potentially lethal, because these even numbered carbon chains, as would 6--fluorohexyl on the indolic or indazolic 1-position nitrogen, these chains get metabolized into fluoroacetate. AKA the poison ten-eighty, its LETHAL stuff, a metabolic poison because fluoroacetate gets metabolized to fluorocitrate which cannot be processed by the enzyme aconitase within the Kreb's cycle (citrate cycle) of glycolysis and ATP production, making it a truly deadly, nasty metabolic toxin with no antidote, some theoretical ones but not things that hospitals might have on hand. And some cannabinoids, indazolic core mostly with a 1-(5-fluoropentyl)-sidechain on the indazolic or indolic 1-position, that is to say, the nitrogen on an indole ring, or the first nitrogen on an indazole, that were either hyperpotent For example N-cumyl-(1-5-fluoropentyl)indazole-3-carboxylate is fully active within a dose range of a few tens of micrograms, its more potent as a cannabinoid is than fentanyl is as an opioid agonist, FAR more potent, and far shorter lasting, its like the remifentanil of cannabinoids, very difficult to dose, and when I've had it, the typical effect, its been lucky I was lying on my bed, because it was a matter of inhale toke, resting on elbow reading book playing some music, then eyes droop, muscles become hypertonic, get munchies, pass out cold. Instant general anaesthesia. With ONE single toke of a 1mg/1ml solution in propylene glycol/glycerine like the smoke companies make E-liquids. A few breaths were as much as I could physically tolerate using a low voltage battery. This N-cumyl fluoropentylindazolecarboxylate would likely have been rejected if many others, like the benign CP-series cannabinoids were left alone. Then things with a 3-methylvalinyl sidechain on the 3-position, that is to say, 3-tert-valine based sidechains appeared and these actually proved lethal poisons in addition to cannabinoid effects. Got popular for a brief time with users in estonia and other parts of eastern europe before it was realized how deadly they were. I don't know the mechanism of toxic activity. But people were taking one inhalation and dropping dead. Even full agonist (THC is a medium strength partial agonist of CB1 receptors) which is why THC is impossible more or less to OD on, whilst the full agonist cannabinoidergics can be quite dangerous. In overdose, but not like these 3-(3-methyl)-valine subbed indazolic cannabinoids, some of the FUBINACA analogs were responsible IIRC.
Would like to overlay 3D structure with leelamine and certain other pyruvate decarboxylase kinase inhibitors, those would fuck with the ATP generation processes alright, just to see if that is an incidental pharmacophoric crossover.
