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Questions for Lestat: Lestat's Lab
Lestat:
Ran out? can help with that wolfy. And no worries, wasn't going into specifics, merely pointing out the way the noxious crap in fiddleheads acts, you can draw your own conclusions from that data well enough.
Fucking poor rotten unfortunate bastards, starving to death whilst having food to eat. Rough way to go, I bet it was slow as hell before it killed those explorers.
And as for do I have a use for thiaminase? as it happens, methinks I may well just do. Would be neat to try an enzymatic synthesis of chlormethiazole, for the cleavage step to replace bisulfite/metabisulfite, and save me an annoying, tedious, stinky sulfurous workup and tons of sulfur dioxide to deal with. If I could do it enzymatically it would be perfectly clean, just heat sufficiently afterwards to denature the thiaminase, and no nothing, as far as working the intermediate thiazolylethanol up is concerned.
Theres TONS of bracken round here. I'd sooner use a fern species that doesn't contain ptaquiloside though, or cyanide. The cyanide I can deal with but those illudanes are fucking heinously toxic. I'd need to make DAMN sure it didn't follow through, distil the chlormethiazole freebase, check it by TLC etc.
Intrigiungly enough, ptaquiloside shows great structural similarity with a pair of toxins from the mycological sphere, illudin-S and illudin-M, from mushrooms in the genus Omphalotus, the jac;'o'lanterns, so called for the eerie green glow of the bioluminescent gills. Although I haven't ever seen any of them in the wild, Omphalotus olearius grows here in the UK, but its very, very VERY rare, with only a handful of recorded sightings in the UK. They are primarily a genus of hotter countries, that species associates itself with olive trees mainly iirc, but theres a host tree available in the UK, oak i think, or possibly sweet chestnut.
Won't kill if eaten usually if ever, but they do make unfortunate pickers that mistake them for the edible and very tasty chanterelle, but those never have true gills, merely forked, shallow pseudogills, just ribs baring the fertile hymenium, where Omphalotus all have very decurrent true gills, and always grow on wood, which the chanterelle does not ever do., the interesting bit, is that the illudins (not illudANES on the whole, but specifically illudin-S and illudin-M were looked at as lead compounds in the search for new anticancer stuff.
Makes me wonder if the pharm companies thought to examine ptaquiloside in a high throughput screening
WolFish:
i am back on stimulants, no worries there.
and the fiddleheads have gone the way of most things i want to try these days. they were canadian, the only diff i can think of, and it took three tries before the water didn't turn brown. then two boilings to get that water clean. i tasted a little bit of one and it was - green. probably why i like them, i like things that taste green. at any rate i put the in the fridge a week ago and forgot to put the top on. i will be tossing them today. usually i eat a few before that happens, but i probably was too wary of so much brown in the water.
i buy my mushrooms in the grocery store and i don't always trust them since our grocery store is of less desirable provenance.
Lestat:
Well I'd trust your mushrooms a lot more than I would your (or anyone elses, or anywhere elses of any KIND elses) fiddleheads.
Although I hold things that taste green in the highest and most putrescent degree of tartarus-sharted unspeakable abomination.
Although I don't know what ptaquiloside looks like in isolated form. The green glow of the Omphalotus spp (the jackolantern mushrooms) is from, as far as I know, a luciferin-luciferase type reaction like is used by glow-worms and fireflies. But generally brown things in water....well....you know whats brown and gets dropped in water (usually), right?;) lol.
Not laughing at your fiddleheads going off mate, not laughing, and not at your misfortune. But I won't either claim that I do not believe it MISfortune at all. Sorry you spent on them and didn't get to enjoy, but
those things are BAD news. And I am as sure as I can be, that for wolfies they are worse. Not that vegetables really get much worse. Well there are cycad seeds and ODAP, but thats just...way beyond nasty as hell *shudders* poor fucking bastards*
WolFish:
guess i shouldn't eat grass either?
no clue what kind it was; when i was a kid i ate anything growing in fields and away from dog walking places.
now it's limited to things like asparagus, which also tastes green. these days even the pristine fields are not so anymore.
Lestat:
Probably not, no. That'd make you a sheep in wolf's clothing :P:P:P
On the whole I doubt its likely to do you any harm, but people aren't meant for digesting cellulose. Even most grass-eaters depend on microbial gut populations, extensive fermentation, or both to do it. Termites even cannot themselves digest cellulose, its only because of their gut flora that they are able to.
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