I've had bad side-effects from 6 anti-depressants or anti-depressant-type meds so far. Fluoxetine and sertraline gave me anxiety, paranoia, perceptual disturbances, violent urges and homicidal ideation, lofepramine and venlafaxine made me sleep for 12-18 hours a day and feel exhausted all the time, mirtazapine dried up my mucus membranes and atomoxetine dried up my mucus membranes, gave me constipation and made me feel constantly fatigued, shitty and completely unmotivated. None of them actually helped, as far as I could tell.
I think my brain doesn't get enough dopamine, and that boosting the synaptic concentrations of other neurotransmitters just pushes it even further off balance. Amphetamine increases synaptic dopamine levels, and it's given me significant and wide-ranging improvements without much in the way of negative side-effects.