To be fair, you don't need to take opiates not to understand 'ebonics' messed with for comedic effect.
When you mix up words like 'ask' and 'axe'...if someone were to inquire 'can I axe you', I'd more think it odd that somebody wanting to commit brutal murder waited for permission.
And to be fair, I've always had that effect, speech wise. It happens to NTs to (on the recipient end) and has done so since long before any opioid had ever entered me. At least not unless my mother had an epidural.
Its got little to do with opioids. Happens when I'm NOT dosed yet, and chemists/biologists and physics types can understand me just fine.
Derez nuffink rong wiv me brane.
Its when I'd end a joke like that with a joke about brane-world theory and explanation to the best of my ability of what braneworld cosmology is that people get lost. People on the spectrum have an easier time of it than most, because I don't have to dumb it down.