Woke up, picked my meds up, and spent the day lazing around posting on forums and reading some article from Journal of Applied Toxicology, centered on identifying the binding site for the nootropic drug huperzine-A, an anticholinesterase derived from a chinese clubmoss, Huperzia serrata (and others of the genus), it does strongly inhibit acetylcholinesterase, but also acts as an NMDA antagonist, although one would be poisoned nerve agent fashion before ever getting dissociative effects.
I thought it bound the glycine or perhaps the polyamine regulatory site, but oddly it turns out to be an ion channel pore blocker, binding to the PCP site. Still trying to have people hunt down the full text of the article for me though.
I think I'm going to make another bottle of orange juice up in case I get thirsty at night, have a smoke before shooting up the morphine/oxycodone mixture I didn't finish and is still laying in my mortar and pestle ready for banging up and curling up in bed with my book on biochemistry I got out of the library for just this sort of lighthearted bedtime reading:); so far, I've been learning a fair bit, and finding it a really interesting book, the title is 'Harper's illustrated biochemistry, 3rd edition'
