Twatting hell. I've A-got the shits, and B-need to go all around the city, after first picking up some xylene, another sodding expensive I didn't want. I think I'll head to the first pharmacy I pass and pick up some of those oral melting immodium and use the entire pack. Because I don't need the fucking squirts whilst precursor-hunting throughout an entire sodding buggering bastarding city and two or three outlying towns. No, no I do not.
I just gave myself a solid shot of IM morphine and am waiting for that to kick in, before I go out, and snorted the contents of some oxycodone IR capsules, not for pain relief this time, but because (most) opioids block one up, so to speak. Its how immodium works, by binding to opioid receptors as an agonist, in the gut, its just that it doesn't cause a high unless massive doses are used because loperamide is pumped back out of the brain by P-glycoprotein, and its not somthing good to have stay up in the brain to begin with, because it forms a toxic metabolite like haloperidol (haldol, the antipsychotic of the butyrophenone class) does, that acts like MPTP and attacks the substantia nigra, a dopaminergic part of the brain responsible for inhibitory control over movement, and thus acts, like MPTP, to cause a chemically induced parkinson's disease, although it appears to be far less toxic than MPTP, which causes instant, ultra-parkinsons, someone poisoned ends up paralyzed and locked in a useless shell of their body, whilst their mind is left to scream and scream and scream and scream and scream inside. But in the case of loperamide, people have used either p-glycoprotein inhibitors and other metabolic tricks, or figured on overwhelming pGP using megadoses (100s of mg) of immodium (jesus I bet they didn't shit again for a month!) and saturate the method the body uses to reject it from the area past the blood-brain-barrier and after doing so, it proving to be a very strong opioid; even causing someone to go over and require multiple naloxone injections in hospital (reported very, very long duration of action, days) and this individual was, IIRC tolerant to opiates possibly an addict.
I'll stay away from loperamide analogs though, too dangerous potentially, although the original, peripherally restricted drug is going to get bought and used ASAP, as soon as the oxycodone and morphine finishes making me itch like I've got fleas and making me euphoric. Right now I want not to fucking need a battery acid shit so I can go grab the xylene I want, buy some more gas mask polyvalent filters, some phosphoric acid and a certain other item I need. I don't want to go out, but fuck, I can't just say 'fuck this' and shitcan my work. I don't like going to a bunch of effort and then finding it's come to nowt but a fart.
