Just one quick bitch, part two

[odeon]

I have a two-hour presentation this morning but I don't feel prepared at all.

Hope it went well, but then I saw your post that some quoted about not being able to express well.

 

I often stand up in front of a meeting because I have so much to say, then I  ... uhm, well ... I mean  ...  I just   Uhm ... have so damn much to offer to the discussion that I um .. I mean, well you know. I mean really you know, right, so I do not have to say it, right and you all get my meaning now, right?

... been there.  If it is not about what I LOVE and NEED to talk about, you might as well not expect me to do the talking.   

The presentation did go well. My frustration was about this place. The maths discussion, specifically.

I like to present and do it well, most of the time. I seem to have the ability to entertain an audience. I can sometimes have doubts about that ability, especially afterwards--I'm prone to overanalysing my performance when thinking back--but people keep telling me that I do presentations well.

It's in the nature of the beast, I think.

I'm doing one again next week, at a conference in Stockholm.

[renaeden]

I was using drugs that make me eat and never shit. How fucked up could that get!?! 

What were they?
I started benztropine along with my psych meds back in April and boy, the consequences of eating and not shitting were horrible. I thought I was going to have to take laxatives for a long time but thankfully after a few months, the problem went away. That was an experience I won't forget in a hurry.

[Lestat]

It all has to go SOMEWHERE.

Makes me wonder...of late I have been insatiably hungry, and I'm on a combination of two antimuscarinic drugs, scopolamine as transdermal patches, although those are a very, very tiny dose, compared to the same orally. But I'm not sure as the latter could have the potential for central effects, as buscopan (hyoscine/scopolamine butylbromide) is in the form of a quaternary ammonium salt, and is thus charged and unable to pass the blood-brain barrier. But SOMETHING is making me hungry as fuck. Been raiding the cupboards for any traces of things I'd find acceptable and edible, even things I'd not normally bother with. Found myself waking up the other night, in order to eat an entire jar of marmalade from the fridge.

Definitely NOT usual form me.

[DirtDawg]

I have a two-hour presentation this morning but I don't feel prepared at all.

Hope it went well, but then I saw your post that some quoted about not being able to express well.

 

I often stand up in front of a meeting because I have so much to say, then I  ... uhm, well ... I mean  ...  I just   Uhm ... have so damn much to offer to the discussion that I um .. I mean, well you know. I mean really you know, right, so I do not have to say it, right and you all get my meaning now, right?

... been there.  If it is not about what I LOVE and NEED to talk about, you might as well not expect me to do the talking.   

The presentation did go well. My frustration was about this place. The maths discussion, specifically.

I like to present and do it well, most of the time. I seem to have the ability to entertain an audience. I can sometimes have doubts about that ability, especially afterwards--I'm prone to overanalysing my performance when thinking back--but people keep telling me that I do presentations well.

It's in the nature of the beast, I think.

I'm doing one again next week, at a conference in Stockholm.

GODSPEED, my friend. 

As I mentioned, if I am just forced to be charged up about generalities I often fail, but when it is MY OWN topic, I often do quite well, much like what you describe. 

Being coerced or even forced to "stand up and deliver" often leaves me with nothing to say, even using a specific set of notes. All the sudden nothing is as important as finishing the speech/diatribe.   

Glad it all came out OK.  Break a leg on the next one!!  The maths discussion is a "ballunacy" of hot air, ever rising to the troposphere and beyond. LOL

[DirtDawg]

I was using drugs that make me eat and never shit. How fucked up could that get!?! 

What were they?
I started benztropine along with my psych meds back in April and boy, the consequences of eating and not shitting were horrible. I thought I was going to have to take laxatives for a long time but thankfully after a few months, the problem went away. That was an experience I won't forget in a hurry.

I was taking four to six Percocets a day at first, then on to a lesser oxycodone, but still quite powerful.  Known to cause constipation, these types of opiates also stimulate ones appetite. That is what I meant. Eating everything in sight and NEVER able to SHIT!

It would be like holding a bowling ball that is too large for you and when get to the end of your swing, you can not get your thumb out of the ball, because it is STUCK!!. 

[Lestat]

Heh, I know what you mean there. oxycontin is a right bugger for that. Generally, I'll shoot 2 80s, and then end up heading straight for the nearest sweet, sugary food.

Lime marmalade with the shredded peel, straight from the jar is a favourite, or a big mouthful of runny honey.

Although it seems to have the opposite effect too, very salty food, I find pickled olives irresistible on oxy. And hot spicy stuff, although I love spicy food any time, anywhere, I've been known to drink tabasco sauce straight from the bottle whilst nodding.

[TheoK]

I was using drugs that make me eat and never shit. How fucked up could that get!?! 

What were they?
I started benztropine along with my psych meds back in April and boy, the consequences of eating and not shitting were horrible. I thought I was going to have to take laxatives for a long time but thankfully after a few months, the problem went away. That was an experience I won't forget in a hurry.

I was taking four to six Percocets a day at first, then on to a lesser oxycodone, but still quite powerful.  Known to cause constipation, these types of opiates also stimulate ones appetite. That is what I meant. Eating everything in sight and NEVER able to SHIT!

It would be like holding a bowling ball that is too large for you and when get to the end of your swing, you can not get your thumb out of the ball, because it is STUCK!!.

Ask your doc for papaverine. It will decrease the constipation.

You can send me some oxy for the good advice. I'm almost out of mine, and I don't have a prescription 

[Lestat]

What good advice? papaverine is an antispasmodic and vasodilator, I find it most unlikely it would increase gastric motility per se.

And potentially dangerous advice at that, due to the long list of potential side effects.
And in any case, simple stool softeners based on macrogol, or other gel-forming polymers, etc., bulking agents are the safest for use as an adjunct to opioid use to prevent or treat constipation, they aren't habit forming (unlike the opioids themselves of course)

I find I don't even need to use it daily, but I get a macrogol-based softener called laxido, its a powder thats dissolved in water for oral use, meant to be orange flavoured, but I find it takes a teaspoon or so of citric acid and a little sugar to make it more acceptable. It isn't foul, its just, insipid, kinda, the hint of an orange taste is irritating when its just there in the background and barely perceptible. Few of those a week and all is well with the plumbing, at least, from an opioid-related point of view.

It works wonders when it comes to stopping the 'just gave birth to a porcupine stuffed full of bricks' shits.

[odeon]

Such an informative board, this.

[神]

@Lestat:

Also don't forget home remedies, like drinking coffee extract with lots of aspartame and smoking in excess.

Nothing really cures opioid constipation though. The problem has been known for more than a millennium.

[Lestat]

Not true...

Methylnaltrexone underwent phase III trials in IIRC 2005, and was approved either 2008/2008 in the US,  its a quaternary ammonium derivative of naltrexone, the opioid antagonist, which cannot cross the blood-brain barrier and thus is incapable of causing withdrawals.

That said, in an already dependent user, it would have to be managed most carefully to avoid peripheral....unpleasantness of a rather spectacular nature.

Naltrexone itself on the other hand is capable of putting someone in hospital, the precipitated withdrawal can be that severe. Although it does have potential use in opioid users in tiny doses.

I'm currently trying to persuade my doc to let me trial it actually, although it will require normally dosed tablets and a serial dilution in water, or other suitable solvent, pretty trivial to do without issue. I don't think there is any currently marketed microdose formulation, although there are combined morphine/ultra low dose NTX and similar with oxycodone available.

The idea being to both inhibit existing tolerance, and retard development of further tolerance.

Based on some of my research it seems that the mechanism of action is possibly through targeting some rather interesting splice variants of the mu-opioid receptor, and also through blocking the activation of a subpopulation of Mu-ORs that are excitatory and pro-hyperalgesic in nature rather than inhibitory, as per classical opioid effects. Presumably this subpopulation binds NTLX with far higher affinity than it does towards the intended target.

[DirtDawg]

Such an informative board, this.

All that shit is available if one reads the drug warnings, presented with each prescription.

What I am treating my constipation with is more fiber, fresh vegetables and fruit along with trying to increase my water intake.  I prefer not to complicate one drug with another.  I NEED the pain meds, but adding more drugs to help me shit seems wrong.

[Semicolon]

Such an informative board, this.

All that shit is available if one reads the drug warnings, presented with each prescription.

What I am treating my constipation with is more fiber, fresh vegetables and fruit along with trying to increase my water intake.  I prefer not to complicate one drug with another.  I NEED the pain meds, but adding more drugs to help me shit seems wrong.

We are the Aspie FDA.

[Lestat]

Thats the great thing about the macrogol type stool softeners, its just an inert polymeric bulking agent, that fulfils a similar purpose to a high fiber intake (not a substitute for a good diet, but its not really a drug as such, just bulking agent, like ispaghula husk, along with a portion per dose of a balanced spectrum of electrolytes)

I do sympathize a lot though in particular with your chronic pain. What did you do? I'm getting really fed up of my knee and hip. Bursitis of the hip is no fun at all, without the oxy, and often supplementary OTC opioids (as codeine/opium/morphine based cough mixtures), it makes every single step taken feel as though some dirty great brute is using a sack full of hot bricks to drive nails into my hip and lower spine. I've had burns from molten metals spilled onto my skin that hurt less, even when I scarred the everloving bejeezis out of one of my hands due to a mishap involving perchloric acid, the deep second degree burns hurt much less. Which is saying something.

And the leg cramps...fuck...ow. Even slamming a bit short of a gram of oxy at a time sometimes, it doesn't cover it up, and I have to take a muscle relaxer (tizanidine, best one I've ever found) with it.


Ahem..that will be autie FDA to you matey 
And without the corruption that is entrenched in the FDA. FDA can lick my nackers (for a financial consideration)

[DirtDawg]

Such an informative board, this.

All that shit is available if one reads the drug warnings, presented with each prescription.

What I am treating my constipation with is more fiber, fresh vegetables and fruit along with trying to increase my water intake.  I prefer not to complicate one drug with another.  I NEED the pain meds, but adding more drugs to help me shit seems wrong.

We are the Aspie FDA.

Thank you!  Glad I could be here tonight!!  I love This PLACE.

:takes a rockstar bow:

We love this Place!!!!

... uhm,  wot?