In the case of S.divinorum, there are two strains in existence, and it has been that way for a long, long, long time. Since before the days of the spanish conquistadors rampaging and raping, pillaging and murdering their way through south america. The missionaries inevitably tried to stamp it out, but in evitably, thats something such conquering shits don't manage. Real bunch of bastards, like Cortez, etc.
There might be a third strain, not sure on that one. In its native environment, that too, made it hard to extirpate, with it growing deep in the siera mazateca cloud forests.It very rarely sets seed, and when it does the seeds are usually nonviable, and instead; Salvia divinorum propagates itself in the wild, by the mature plants bending over towards the ground, having developed rootlets, and when in contact with the ground, after they droop down, the rootlets set themselves into the soil and new plants grow.
Also people grow it by cloning, in a primitive sense, from these two strains, by planting sticks of the plant stem in the ground.
I'd quite like to add S.divinorum to my gardening, make my own extract and refine the salvinorin A down to white crystalline material. And then first cleave one of it's ester linkages to form the non-psychotropic salvinorin-B. This can be used as a jumping off point, a precursor for some intriguing Salvinorin relatives. Some of them potent kappa opioid receptor (KOR) agonists, some more potent than salvinorin-A. And more interesting still, a compound known as Herkinorin, a modification of the neoclerodane diterperpenoid salvinorin-B, its a Mu-opioid recepto agonist (same as your morphine, your vicodin, your oxycodone, diamorphine, they are MOR agonists, Mu-ORs are your classic opioid receptor, the others being kappa, DOR, the delta-opioid receptor) and the nociceptin receptor, which seesms to have something to do with tolerance regualation to MOR agonists.)
hiHerkinorin is....different, to other MOR agonists (and itt is quite a potent one, by every bit of reading I've done on herkinorin.
It's a biased agonist, selective for certain intracellular second-messenger cascades over others, in particular it doesn't induce intracellular recruitment of beta-arrestin II; which causes tolerance to opiates, in those MOR ligands which DO induce beta-arrestin 2 recruitment, OR induce receptor internalization (where receptors are dragged inside the cell, brought to the lysosome and broken down, whilst new receptors need to be biosynthesized before tolerance etc. etc. is back to normal.)
Seems worthy of some time extracting a large amount of S.divinorum, cleaving the eser with base, it just needs the acetyl ester cleaved, and then using a system of pyridine and para-dimethylaminopyridine to effect hopefully, formation of the benzoyl ester wheere there acetyl used to be, with high yields, if using 4-DMAP, and soaking up the HCl from the benzoyl chloride when it acylates the alcohol moiety freed up when cleaving salvinorin A, using 4-DMAP and pyridine together often allows acid halides and acid anhydrides to form the esters desired at room temperature and within minutes, as opposed to say, an acetylation with acetic anhydride and pyridine or a little triethylamine and needing several hours at 90 'C >. z
Would be most intriguing work, and its something that I could easily manage'
Quick bitch: I just spotted something I needed at a price for an amount that'd last me fucking ages on ebay, but while I had enough money in my damn account to pay the seller, shipping etc., the stupid bastardized piece of dog shyte kept redirecting me tto something to do with my bank asking further details for security, only, when I put my details i, the seller redirected me automatically to the shitting well bank captcha type thing, over and over and over again. I found I couldn't follow through and actually make the transaction
Was for 2.5 liters of pure nitromethane
That would have lastesd me so damn long and let me bring forth works of psyche-driving art, so many phenethylamines I could have synthed, the exotic ones that no venor eve stocks, not that I trust online vendors of that sort of thing.
So I'm limited to phenisopropylamine counterparts of the phenethylamiines, TMA and DOx analogues, alptha-ethylmescaline, all sorts of the novel and the new, the oddballs in a series, or pair of offballs so comparative analyses can be performed.
Hmph. Buggritall.h
