I took mine at about five AM.
I took Ibuprofen, Parafon and Tylenol in mass quantities about three hours later.
I was having a bad time with my "trick hip," due to all the bent over work I was having to do.
I am OK, now, just a little sore from the hamstrings , mainly from too long of a bike trek in the early AM. (meds will not fix that; only more bike treks!!)