The next great war. I hope millions of people die!
We may get lucky, and it'll be billions this time.
But there's good news on that situation, the U.S has recently transferred bunker buster bombs and other bombing munitions to Diego Garcia, located in the Indian Ocean. This joint U.S/UK base on the island, happens to be a strategic position for any warfare involving the middle east. This base was also used to support bombing aircraft for the Iraq war. So going by this transfer of bunker busters munitions to there, and the increasing rhetoric against Iran, you get the idea. But the beauty is now that, the Russians want to help Iran start it's first reactor in northern hemisphere summer time... So war is likely coming soon.
Anyway, I looking for to the downfall of humanity and Earth's first somewhat hostile contact with an intelligent alien species. In that order.