Yes. The hull is a complete loss and will never fly again.
This is very sad because the PA-46 is powered by a 350 horsepower Turbocharged Continental TIO-550A3.
This model was pressurized and had an operation celing of 28,000 ft.
It can no longer fly to 28,000 feet, it can only sit on the ground because the engine and fuselage were damaged beyond repair.