Morphine (intramuscularly, because the oral BA is bloody abysmal), oxycodone (capsules, IR) (haven't really been keeping track of the dose, couple of hundred mg or so, roughly), just took my seizure meds (chlormethiazole, also a sedative-hypnotic of that almost extinct old-school wallbanger type, a barbiturate binding site agonist at GABAa receptors. Smells funky, melts plastic, fairly narrow therapeutic or recreational index, kick like an angry mule. Very old fashioned, absolute antique sedative-hypnotic and anticonvulsant. Not actually licensed for seizure control in the BNF, but I'm prescribed it anyway, because it works well for me, taking it 3xdaily, but without causing any hideous physical dependency whatsoever, unlike any other GABAa agonist I can think of with any serious potency)
Cimetidine and cyclizine (a stomach acid med and antihistamine of the sedating type respectively) Cimetidine also acts as an inhibitor of CYP-P450 series enzyme pathways that break down morphine and oxy, allowing a higher peak plasma level and longer duration of activity.
Clonidine (an alpha2 adrenergic autoreceptor agonist, blocks noradrenaline release), for suppression of sensory overload crap. And a relative of it, tizanidine, works the same way but a lot more hypotensive (clonidine is also used as a blood pressure lowering medication), the tizanidine (zanaflex) is a strong bugger of a muscle relaxer), that's for the nerve damage in my bad leg after the failed knee surgery I had done on it. Left me with a permanent muscle spasm in my calf, hurts like hell at times, but the tizanidine really helps bring the muscle tension down from a painful, tight-feeling knot to relatively comfortable. Anything left over, the morphine and oxy take care of.
Soon, will add some real good brown, and some methadone tablets, just because, in the latter case, it's just an opioid I've always rather liked.
Although when I start at those two, I'll lower the dose of oxy pretty drastically, and temporarily, halt the morphine shots, because I don't want to increase my tolerance to opioidergic medications. I find I'm more all round generally functional using brown, I can moderate my doses much more easily, when vaporizing it from a pipe, as opposed to extracting XR morphine sulfate capsules, with the methadone to fine-tune things to just the right point between functionality day to day and pain control.
