Unlikely pappy. I used to, in my younger days, be a lot less careful, got bitten a few times by different things., but now with new stuff I run it up stepwise, unless potency is a known factor (e.g if something was say, fr.ex, 10x as potent as morphine, in the opioid field, I wouldn't push it further that about 100mg, and not that, at first. Trying something at first that is a total unknown and with absolutely bollocks all data on the compound, or even anything similar I could get the most rough ass ballpark figure from, such as the, as far as I can tell, as yet un-made and untested phenethylamine (potential) psychedelic plus its amphetamine, cathinone and possibly even phentermine analogs, 3-bromo-4-(1,1-difluoromethoxy)-5-methoxyphenethylamine, an analog of mescaline with a difluoromethoxy group replacing the 4-position (a critical carbon on the phenyl ring in the phenethylamine and amphetamine/cathinone psychedelics determining type of activity if any) with bromine replacing the 3-position methoxy, swapping out the two electronpositive groups for very electronegative groups that pull electron density away from the aromatic ring, which should change the binding and affinity, efficacy as a serotonin 5HT2a receptor agonist and at 5HT1a pre- and post-synaptic receptors. Not too well up on 5HT2b and 5HT2c (5-HT stands for 5-hydroxytryptamine, aka the neurotransmitter serotonin itself) binding in mescaline and analogs compared to the 2,5-dimethoxy-4-substituted phens, phets and cats, but with the 2C-x series (2,5-dialkoxy-4-xyz substitution pattern, rather than 3,4,5-position carbons bearing the substituents on the aromatic ring, like mescaline and TMA, TMA-2, etc., the TMA series being alpha-methylmescaline analogs with the numbers denoting relocation of one of the methoxy groups to another position on the phenyl ring, basically positional isomers of the amphetamine version of mescaline)
This, or indeed, and I searched HARD for quite some time to find even slight similarities, and all I could find was difluoromethoxymescaline, where 4-difluoromethoxy replaces 4-methoxy. But NOTHING whatsoever with both a 4-difluoromethoxy and a 3-substituent of a highly electronegative nature, like a halogen atom, nitro, trifluoromethyl or cyanide group. Or even with just an electron withdrawing substituent on position 3. It, as far as I can tell has never been done. Or if it has, its been done in private labs like my own, privately owned by citizen chemists, and not organized uni research departments, and whoever, if anyone, thats made it and tasted it hasn't spoken of it online.
So, it needs to be doing. So, the benzaldehyde is going to be reacted with nitromethane, nitroethane and the propiophenone to react with pthalic anhydride or the equivalent acyl chloride or bromide, to give the substituted pthalimidopropiophenone, that will cleave in stomach acid and release the drug, because primary amine cathinones are REALLY unstable, and rapidly dimerize to inactive, inert total shit. Bright purple useless shit, as it happens, lol.
So protecting as a prodrug seems like a viable option to me, thats acid-sensitive and so cleaves in-vivo. Because it takes about 10-15 seconds in water to to turn to crap, if in a concentrated solution, whilst molecules of the drug get less of a chance to meet up and dimerize, in a more dilute solution, I.e stomach contents, especially since its going to be released in a slower, steadier manner.
This is NEW, so once the benzaldehyde arrives, I will need to run it up really, really slowly from a very low dose (sub-milligram, since its a totally new heteroatom for this position, electropositive to electronegative group switch. Although at least I do know, from difluoromescaline retaining psychedelic activity, that it isn't impossible that this project will turn up a winner.)
currently on just the pain meds, etc. Turned up around a gram of morphine hanging around in a filter paper from the alpha-chloromorphide to desomorphine project. Leftovers, but tasty leftovers that came in at just the right time. Just about finished acylating by now, methinks. time for some workup.
I can't wait to get cracking. The benzaldehyde for it cannot come soon enough. Every time the postman comes lol, I start climbing the walls:P
